Renal function may be further compromised in patients with heart failure, hypovolemia, cirrhosis, nephrotic syndrome, or hypoalbuminemia. Ibuprofen may impair the ability of the kidney to cope with low renal blood flow states due to inhibition of prostaglandin-dependent afferent arteriolar vasodilation. Renalįrequency not reported: New or worsened renal insufficiency, nephrotic syndrome with and without renal failure, acute renal failure due to tubulointerstitial nephritis, papillary necrosis, and acute tubular necrosis Ibuprofen should be used with caution in these patients. Patients with a history of serious gastrointestinal events or alcohol abuse are at increased risk for severe gastrointestinal side effect. The incidence of gastrointestinal blood loss with ibuprofen is dose-related, occurring in up to 17% of patients receiving 1,600 mg per day and in 23% of patients receiving 2,400 mg per day. In addition, a case of ibuprofen-associated colitis has been reported. More serious gastrointestinal effects of ibuprofen are uncommon but include occult blood loss, ulcer, gastrointestinal hemorrhage with or without perforation, and pancreatitis. Rare (less than 0.1%): Aseptic meningitis, paresthesias, and pseudotumor cerebriįrequency not reported: Headache, drowsiness, dizziness Gastrointestinalįrequency not reported: Nausea, dry mouthįrequency not reported: Dyspepsia, nausea, diarrhea, abdominal pain, flatulence Very common (Greater than 10%): Drowsiness, sedationįrequency not reported: Impaired motor skills, dystonic reactions, delirium The incidence of aseptic meningitis associated with ibuprofen is higher in patients with systemic lupus erythematosus and other connective tissue disease, although it has been reported in patients without such underlying disease states. Delirium has been reported in elderly patients with mild dementia following a small oral dose of diphenhydramine. Dystonic reactions have been accompanied by dizziness, mental confusion, rigidity, lip and tongue protrusion, trismus, torticollis, and swallowing difficulties and generally resolve spontaneously. The plasma concentration threshold for sedation is 30 to 42 ng/mL, and to cause mental impairment is 58 to 74 ng/mL. The CNS depressant effect of diphenhydramine parallels its plasma concentrations. Uncommon (Less than 1%): Elevated blood pressure Nervous system Cardiovascularįrequency not reported: Hypotension, tachycardia, palpitations The more commonly reported adverse effects include drowsiness and dyspepsia. vomiting of blood or material that looks like coffee groundsĪpplies to diphenhydramine / ibuprofen: oral capsule, oral tablet.swelling of the face, fingers, feet, or lower legs.pain or discomfort in the arms, jaw, back, or neck.inability to move the arms, legs, or facial muscles.Although not all of these side effects may occur, if they do occur they may need medical attention.Ĭheck with your doctor immediately if any of the following side effects occur while taking diphenhydramine / ibuprofen: Incidence not known Serious side effectsĪlong with its needed effects, diphenhydramine/ ibuprofen may cause some unwanted effects. Last updated on Apr 11, 2023.Īpplies to diphenhydramine / ibuprofen: oral tablet.
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